FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination.

Beschreibung

This article is from The Journal of Experimental Medicine , volume 209 . Abstract During murine B cell development, PI3 kinase inhibits Ig gene rearrangement by suppressing FoxO1, which mediates Ikaros mRNA splicing; Ikaros is needed for Ig gene recombination.